The course of disease in recurrent HSL generally involves several stages. Within the precursor stage, pain, tingling, or burning sensations in the affected area may occur. This is followed by the appearance of a macule, turning into a papule and leading to the formation of a vesicle. The vesicle bursts, and the formation of a soft scab is initiated. Subsequently, the soft scab is replaced by a hard scab. Over time, the scab falls off, and the lesion is fully healed without scarring 6– 8. While healing, the process is often accompanied by symptoms such as pain, discomfort or reduced self-esteem 6. Complete healing takes seven to ten days 7. Sulfatizirani polisaharid, pridobljen iz rdečih mikroalg, tvori aktivno zaščitno pregrado in pomaga varovati pred sončnimi žarki.

Shaw, M. et al. Failure of acyclovir cream in treatment of recurrent herpes labialis. BMJ Open 291, 7–9 (1985). Zahvaljujući svojoj super hranjivoj formuli s prirodnim voskovima i aloe verom, Herpatch balzam za sprječavanje herpesa smiruje, hidratizira i obnavlja osjetljive i ispucale usne, ali i daje dugotrajno olakšanje.

Zahvaljujući inovativnom i učinkovitom načinu nanošenja, serum Herpatch Herpes Serum stručnjak je za liječenje herpesa na usnama. Al-Waili, N. S. Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions. Med. Sci. Monit. 10, 94–98 (2004).

An alternative is provided in the Compeed Invisible Cold Sore Patches that include no antiviral ingredient (Compeed; Johnson & Johnson Santé Beauté France SAS, Sézanne, France). The cytotoxicity was tested on fibroblasts. Further studies examined the irritation of the patches on rabbits and the sensitivity on guinea pigs. The outer layer of the patch consists of a semiocclusive polyurethane film, which allows excessive wound exudate to evaporate while keeping the lesion moist, ensuring an optimum moisture level. The patch seals the wound and arranges ideal conditions for wound healing. The patch functions as a shield, protecting surrounding areas from infection. As soon as the first symptoms occur, the patch is placed on the lesion, replaced if required, and worn for 24hours until complete healing occurs 19. Subjects were excluded if they showed limited compliance, suffered from severe illnesses, or had taken antibiotics or anti-inflammatory drugs two weeks ahead of participation. Pregnant or breastfeeding females were excluded. Hypersensitivity against the ingredients contained in the products or alcohol or drug abuse were additional exclusion criteria. If the patient had already applied a product for the treatment of HSL on the present lesion or had participated in a different clinical study, the subject was not allowed to participate. As a sufferer of cold sores all year round this little tube is a life saver. Due to design of the tube (looks like a lip gloss once opened) it can be applied directly to the affected area. I made sure I gave it a good wipe after application though as I wouldn’t want to risk spreading to other areas of my mouth. The course of disease in recurrent HSL generally involves several stages. Within the precursor stage, pain, tingling, or burning sensations in the affected area may occur. This is followed by the appearance of a macule, turning into a papule and leading to the formation of a vesicle. The vesicle bursts, and the formation of a soft scab is initiated. Subsequently, the soft scab is replaced by a hard scab. Over time, the scab falls off, and the lesion is fully healed without scarring 6, 7, 8. While healing, the process is often accompanied by symptoms such as pain, discomfort or reduced self-esteem 6. Complete healing takes seven to ten days 7.Korr, G. et al. Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control. BMC Infect. Dis. 17, 471 (2017). Carson, C. F., Ashton, L., Dry, L., Smith, D. W. & Riley, T. V. Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis. J. Antimicrob. Chemother. 48, 450–451 (2001). To produce significant results, the sample size was estimated with the programme G*Power 3.1.9.2 23. A sample size of 180 patients (60 participants per treatment group) was calculated with a statistical power of 0.8, an alpha error of 0.05, and a 15% drop-out quote with an effect size of 0.5. All data were statistically analysed with the program SPSS 24.0. Herpatch Herpes Serum možete izravno i jednostavno nanijeti na herpes zahvaljujući aplikatoru u obliku tube. Nakon nekoliko minuta bijela krema stvara zaštitni i prozirni film preko mjehurića od herpesa te pomoću sastojaka pomaže u ubrzavanju procesa zacjeljivanja. Herpatch Herpes Serum djeluje na simptome u svim fazama izbijanja herpesa. Gently apply a small amount of serum that will form a film on the cold wound, adequately covering the lesions and a margin of healthy skin around them. After a few minutes, the white serum forms a transparent protective film on the cold wound. If necessary, the serum can be reapplied every 3-4 hours until the cold wound is completely healed. The film can be removed, if necessary, with hot water.

Faul, F., Erdfelder, E., Buchner, A. & Lang, A. G. Statistiacal power analysis using G*Power 3.1: Test for correlation and regression analyses. Behav. Res. Methods 41, 1149–1160 (2009). The subjects participating in this study needed to be between 18 and 65 years and were excluded if they showed any painful illnesses of the teeth or gingiva. Most importantly, the outbreak of the HSL could not have occurred more than 24hours ago. Spruance, S. L. et al. High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies. Antimicrob. Agents Chemother. 47, 1072–1080 (2003). Aktivni kisik ubrzava obnovu stanica, povećava hidrataciju kože i stoga smanjuje vrijeme zacjeljivanja oboljele površine izazvane herpesom;Active oxygen will accelerate cell renewal, will increase the moisture in the skin and therefore decrease the healing time of cold sore lesions;