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SARS-CoV-2 effects on the ACE2 receptors have been associated with severe inflammatory activity and a poor prognosis, depending on the co-morbities of the patient and other associated risk factors.
Low doses, controlled concentrations, and diluted BVs trigger a range of anti-inflammatory responses ( 61, 62), and have been deployed for management of diabetes, rheumatoid arthritis (RA), heart disease, obesity, asthma, skin diseases, and central nervous system-associated diseases, such as Alzheimer's disease, Parkinson's disease, and sclerosis ( 61– 64). OUR SKIN DOCTORS PROMISE: With over 15 years of experience, we believe in providing professional, affordable, topical cosmeceutical skincare solutions which deliver visible and long-lasting results without the need for cosmetic surgery. BV phospholipase A 2 (bvPLA 2-H34Q) is membrane-binding and links antigens within the cell membrane of human DCs in vivo. Powerful ingredients such as snail mucin and Bee Venom help to heal acne, fade acne scars, brighten skin tone, and maintain hydration throughout the day.Conjugation of BV peptides with hormone receptors and gene therapy offer to positively modulate immune responses applied offer targeted anticancer and anti-inflammatory therapies ( 67). But one large study shows that injecting bee venom into the skin at certain points in the knees and back might improve pain and function in people with osteoarthritis of the knee. SARS-CoV-2 directly interacts with angiotensin-converting enzyme 2 (ACE-2) receptors in the human body. Melittin has been shown to suppress inflammatory pathways and reduce inflammatory markers, such as tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) ( 10, 11).
Human IL-1 receptor (anakinra) also shows anti-inflammatory activity ( 72), however information linking this receptor and Bee venom remain sparse.Keneth Iceland Kasozi 1,2 * Gniewko Niedbała 3 * Mohammed Alqarni 4 Gerald Zirintunda 5 Fred Ssempijja 6 Simon Peter Musinguzi 2 Ibe Michael Usman 6 Kevin Matama 7 Helal F. Mast cell maturation is driven via a group III phospholipase A 2-prostaglandin D2-DP1 receptor paracrine axis. APi M has the ability to suppress tumor growth in breast, liver, prostate, and lung cancer cells ( 111, 112). Host cells are infected through the angiotensin-converting enzyme 2 (ACE-2) receptor ( 8, 9), associated with both innate and acquired immunity ( 10). Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.