You know it's time to think about putting up the decorations when you hear Chris Rea's Driving Home For Christmas. So it was for me as I took in the sights, sounds and aromas of Llandudno Christmas Extravaganza.

I mooched about Madoc Street and Trinity Square to see what was on offer. Families were keeping warm after booking heated "igloos" in the grounds of Holy Trinity Church, Walking in the Air was emanating from a simulator ride and there was waft of alcohol from a mulled wine stall. Dr Christmas explained that he had been a Consultant in Tayside since 2006 working in a Nationally funded, supra-specialist Advanced Interventions Service (AIS). With the main focus of the unit’s work being on treatment-refractory depression and OCD, he began with a few statistics relating to each condition. I’m A Celebrity hosts Ant and Dec have admitted they might be in hot water for a cheeky joke (Picture: ITV)These guidelines are never absolute and perhaps even more complex in relation to OCD: previous failed trials of 3 selective serotonin uptake inhibitors (SSRIs) including clomipramine, 2 augmentation trials (including risperidone) and 1 ‘intensive therapy’ trial. That's what I said upon finding this on the shelf in my local library. I love that. When something you would have anticipated the arrival of, had you known it was about to exist, is just There one day. Hurrah! The sheer quality of English sparkling wine has long since seen off the sceptics, but the pricing can still sometimes be a little ambitious. Not here: this wonderfully bright, lemony but yeasty-savoury-salty cuvée is easily as good as many champagnes that are double the price.

It is believed David Tennant will regenerate into Ncuti Gatwa during the third special, as it has already been confirmed that Ncuti will be appearing in his first full episode for the Christmas Day special. The actor's first series will then start properly in 2024. But about the book... I know David isn't for everyone. I know some find it garish, but I'm not one of those people. I might develop a staring problem looking at this book because David Small is SO. DAMN. GOOD. The expressions are perfect and funny, as usual, and his painting achieves a feeling of texture I've truly never gotten from any other picture book. References to earlier books (running down the street with nothing but a winter hat and boots on, for example) make a person "HA" outloud. And those snowman pajamas... I want a pair. Dr Christmas then moved on to describe several newer brain stimulation therapies for depression, concluding that none is close to coming into routine clinical usage at present. Dr Christmas summed up by saying that for depression there is little new; ketamine is interesting but currently too short-lived to be useful. Possibly the use of psychedelic agents will be a future area for research. Most developmental work is in neuro-stimulation but there are few really useful outcomes of this to date. For OCD, the best advice is to use existing drugs better and, where tolerated, in higher doses. DBS may be better for OCD than depression but this is not yet substantiated. Major depression affects 13% of people in their lifetime and almost 4% of the population within any 12 month period. It is twice as prevalent in women, most commonly starts in the 3 rd decade, lasts more than 2 years in up to 20% of sufferers, and has a 35% recurrence rate.The modern renaissance of winemaking on the slopes of the active volcano Mt Etna has produced some of the most exciting and distinctive red wines anywhere. Fragrant, tomato-tangy, subtly smoky, this is a brilliant introduction to the style, as well being a perfect turkey accompaniment. For millions listening around the world, A Festival of Nine Lessons and Carols, live from the candlelit Chapel of King's College, Cambridge, marks the beginning of Christmas. The service is based around nine Bible readings which tell the story of the loving purposes of God. They are interspersed with carols old and new, sung by the world-famous Chapel choir, who also lead the congregation in traditional Christmas hymns. Application of the term ‘treatment-refractory’ to depression is held by the AIS when the condition is unresolved after 4 or more trials of drugs from different classes , 2 or more trials of psychotherapy or of pharmacological augmentation therapy, and at least 8 ECT administrations. If considering referral for neurosurgical treatment for depression, the thresholds are much higher still. The President delivered a vote of thanks and presented Dr Christmas with a copy of ‘ The Heritage of the Med Chi‘. But of course David is only making a brief return and a new Doctor will officially be taking over the Tardis, played by Ncuti Gatwa. But when exactly will viewers first get to meet their new Doctor?