Symptoms of paracetamol overdosage in the first 24 hours include pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema, coma and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported. Risk factors: If the patient a, Is on long term treatment with carbamazepine, phenobarbitone, phenytoin, primidone, rifampicin, St John's Wort or other drugs that induce liver enzymes. Or With phenylephrine there is a possibility that an increased risk of arrhythmias may occur in patients receiving cardiac glycosides or tri-cyclic anti-depressants. Phenylephrine interacts with monoamine oxidase inhibitors; it should not therefore, be taken by patients receiving monoamine oxidase inhibitors or within 14 days of stopping such medication. Don't take Benylin mucus cough & cold all-in-one relief if you have taken a type of medicine called a monoamine oxidase inhibitor (MAOI) in the last 14 days. MAOIs include the antidepressants phenelzine, tranylcypromine, isocarboxazid and moclobemide, and the anti-Parkinson's medicines selegiline, safinamide and rasagiline. This is because the combination of phenylephrine with these medicines could cause a dangerous increase in blood pressure (hypertensive crisis).

Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required, the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit.

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Undesirable effects are rare with normal doses of phenylephrine, however it can cause the adverse effects typical of sympathomimetics including: hypertension, palpitations (tachycardia), headache, dizziness, vomiting, diarrhoea and insomnia. Urinary retention has also been reported – this is more likely to occur in men with an enlarged prostate (frequency not known).

It's fine to take Benylin mucus cough & cold all-in-one relief with plain ibuprofen or aspirin (assuming these are appropriate for you). However, don't take it with co-codamol, co-dydramol or Tramacet because these contain paracetamol. The concomitant use with other products containing paracetamol may lead to an overdose. Paracetamol overdose may cause liver failure which may require liver transplant or lead to death. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. a) Is on long term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. John's Wort or other drugs that induce liver enzymesThe active ingredients per 20ml are: paracetamol 1000mg, phenylephrine hydrochloride 12.18mg, guaifenesin 200mg, cetylpyridinium chloride 3mg Meanwhile, the following people should get medical advice before taking Benylin all-in-one tablets: This medicine contains 2880mg alcohol (ethanol) in each 20ml dose which is equivalent to 18vol%. The amount in 20ml of this medicine is equivalent to 72ml of beer or 29ml of wine

Pregnant or breastfeeding: Do not use this medicine if you are pregnant. If you use it when breastfeeding, some drugs in this medicine will be present, in small amounts, in your milk. Ask your doctor or pharmacist for advice if you might be pregnant or are breastfeedingThis medicine contains less than 1 mmol sodium (23mg) per dose, which is to say essentially 'sodium-free' serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine) This medicine contains less than 1 mmol sodium (23 mg) per dose, that is to say essentially 'sodium-free'.

Don't take Benylin mucus cough & cold all-in-one relief if you're taking any of the following medicines, because the combination may increase your blood pressure:

Talk to a doctor at once if you or your child take too much of this medicine even if you feel well. This is because too much paracetamol can cause delayed, serious liver damage. Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with the ingredients of Benylin mucus cough & cold all-in-one relief. Just because a side effect is stated here doesn't mean that all people using this medicines will experience that or any side effect.